EARLY EFFECTS OF COBALT CHLORIDE TREATMENT ON CERTAIN BLOOD PARAMETERS AND ON URINE COMPOSITION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 206  (2) , 398-404
Abstract
The variations of some blood parameters and urine composition during the 1st hours after CoCl2 treatment in rats and rabbits were studied. These showed an increase in hematocrit with a decrease in plasma volume and, at the same time, a decrease in total proteinemia and in albumin (rabbits) and .gamma.-globulin fractions. These phenomena are not seen [in rabbits] if the Co is complexed with cysteine before treatment; they are at least partly reversed by cysteine administration soon after Co. Plasma Na+ and K+ concentrations do not show significant changes in CoCl2-treated rabbits; the excretion of such electrolytes and urinary protein content decreases. The urine of CoCl2-treated rabbits contains at least 2 pigmented substances with different MW which are separable by dialysis and DEAE-cellulose chromatography. Both contain Co in different percentages. CoCl2 treatment may lead to an early and profound increase in vascular permeability with depletion of plasmatic material in the tissues and hemoconcentration; the phenomena seem correlated with the forming of Co complexes.

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