Dynamic Kinetic Resolution of Primary Amines with a Recyclable Pd Nanocatalyst for Racemization
- 10 February 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (6) , 1157-1159
- https://doi.org/10.1021/ol070130d
Abstract
A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85−99%) and high enantiomeric excesses (97−99%).Keywords
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