Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin
Top Cited Papers
Open Access
- 1 December 2011
- journal article
- Published by Elsevier in Molecular Therapy
- Vol. 19 (12) , 2178-2185
- https://doi.org/10.1038/mt.2011.201
Abstract
No abstract availableKeywords
This publication has 47 references indexed in Scilit:
- Allele-Selective Inhibition of Huntingtin Expression by Switching to an miRNA-like RNAi MechanismPublished by Elsevier ,2010
- Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG RepeatBiochemistry, 2010
- Huntington's disease: Silencing a brutal killerExperimental Neurology, 2009
- Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease MiceMolecular Therapy, 2009
- Five siRNAs Targeting Three SNPs May Provide Therapy for Three-Quarters of Huntington's Disease PatientsCurrent Biology, 2009
- Sustained effects of nonallele‐specific Huntingtin silencingAnnals of Neurology, 2009
- A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interferenceExperimental Neurology, 2009
- CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing HaplogroupAmerican Journal of Human Genetics, 2009
- Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic miceMolecular Therapy, 2005
- Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansionNature Genetics, 1997