Comparative study of cefaclor and amoxycillin in the treatment of respiratory tract infections in general practice

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Abstract
A single-blind, randomized study was carried out in 101 general practice patients with respiratory infection to compare the effectiveness of 250 mg cefaclor 3-times daily with that of 250 mg amoxycillin 3-times daily. Assessment of 5 specific symptoms was carried out by the doctor before treatment and again 1 week later, and patients recorded their own opinion of any change in their condition. The results suggest that cefaclor was at least as effective as amoxycillin in producing resolution or improvement in symptoms and the median time to maximum response was somewhat shorter. Only 1 patient (on cefaclor) had a side-effect sufficiently severe to warrant cessation of therapy.