Intrinsic-factor Antibody and Absorption of Vitamin B12 in Pernicious Anaemia
- 2 January 1971
- Vol. 1 (5739) , 25-26
- https://doi.org/10.1136/bmj.1.5739.25
Abstract
The mean urinary excretion in a vitamin-B12 absorption (Schilling) test in control subjects was 19·2% and in pernicious anaemia when given with additional intrinsic factor was as follows: no intrinsic-factor antibodies demonstrable 19·3%, antibodies in serum only 14·4%, antibodies in gastric juice only 11·1%, and antibodies in both serum and gastric juice 8·4%. It is concluded that intrinsic-factor antibody exerts an adverse effect on vitamin-B12 absorption in most patients with pernicious anaemia.Keywords
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