A Peripheral Action of o,p′-DDD on Steroid Biotransformation

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Abstract
The in vivo transformation of 3β, 17-dihydroxy-Δ5-pregnene-20-one-7α-H3 was studied in 2 patients before and during administration of 2,2-bis[2-chlorophenyl-4-chlorophenyl]1,1-dichloroethane (o,p′-DDD). The drug diminished biotransformation to pregnane-3α-17,20α-triol, while the formation of Δ5-pregnene-3β,17,20α-triol was unchanged. These results, together with an earlier report, establish that o,p′-DDD, in addition to suppressing adrenocortical secretion, acts as an inhibitor of the enzyme systems responsible for transformation of a 3β-hydroxy-Δ5-steroid to its 3α-hydroxypregnane analog. The inhibition is probably directed toward a 3β-hydroxy-Δ5-steroid dehydrogenase.

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