RhD Hemolytic Disease of the Newborn

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Abstract
Hemolytic disease of the fetus and newborn was first described in 1609 in a set of twins by a French midwife: the first twin was hydropic and stillborn, and the second was deeply jaundiced and subsequently died of what we now call kernicterus. The two conditions were not associated again until 1932, when Diamond et al. demonstrated that hydrops and kernicterus were two aspects of the same disease in which hemolysis of the red cells of fetuses and neonates resulted in extramedullary erythropoiesis, causing hepatosplenomegaly and an outpouring of erythroblasts into the circulation, a condition they termed erythroblastosis fetalis.1 Kernicterus . . .