Coagulation factors in normal and hemophiliac-type swine

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Abstract
A group of general coagulation tests and a specific assay for antihemophilic factor (AHF) was performed on five normal and two hemophiliac-type swine. There was no apparent evidence that an inhibitor of thromboplastin existed. Although the thromboplastin generation test was normal in all animals tested, a modified test employing a dilution technique demonstrated that a plasma abnormality existed in the hemophiliac-type swine. Serum from both normal and hemophiliac-type swine was found to correct the plasma recalcification time of human plasma known to be deficient in plasma thromboplastin component (factor IX). The results indicate that the hemophiliac-type swine are grossly deficient in AHF.

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