Crystal Structure of the Polyketide Cyclase AknH with Bound Substrate and Product Analogue: Implications for Catalytic Mechanism and Product Stereoselectivity
- 17 March 2006
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 357 (1) , 210-220
- https://doi.org/10.1016/j.jmb.2005.12.064
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Enzymes in the biosynthesis of aromatic polyketide antibioticsCurrent Opinion in Structural Biology, 2005
- Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) clusterGene, 2002
- Identification of a Cyclase Gene Dictating the C-9 Stereochemistry of Anthracyclines from Streptomyces nogalaterAntimicrobial Agents and Chemotherapy, 2000
- Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp. The GenBank accession number for acmA reported in this paper is AF043550.Microbiology, 2000
- DnrD Cyclase Involved in the Biosynthesis of Doxorubicin: Purification and Characterization of the Recombinant EnzymeBiochemistry, 1999
- Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase.Proceedings of the National Academy of Sciences, 1996
- Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeusJournal of Bacteriology, 1995
- Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5Journal of Bacteriology, 1995
- Biosynthesis of anthracyclinonesJournal of Basic Microbiology, 1988
- Molecular structure, absolute stereochemistry, and interactions of nogalamycin, a DNA-binding anthracycline antitumor antibioticJournal of the American Chemical Society, 1983