Possible Role of Hyaluronate in Experimental Renal Stone Formation in Rabbits

Publisher Website
Google Scholar
Abstract
Renal stones were produced in rabbits by ligating the right ureter followed by ureteroneocystostomy 1 wk later. Renal stones formed in all animals within 2 wk after ureteroneocystostomy. The components of glycosaminoglycan were measured in the stone matrix, renal tissue and urine by 2-dimensional electrophoresis. Glycosaminoglycan of the stone matrix consisted solely by hyaluronate. Glycosaminoglycan of the control normal urine consisted of only chondroitin sulfate, although hyaluronate was contained in urine in the hydronephrotic and stone forming period. Glycosaminoglycan of the control normal kidney consisted mainly of hyaluronate and chondroitin sulfate, while hyaluronate was the main component of glycosaminoglycan in the stone forming kidney. It is clear that hyaluronate is the most important component of glycosaminoglycan in the early stone forming period.