EXPERIMENTAL-MODEL OF CALCIUM-CONTAINING RENAL STONE FORMATION IN A RABBIT

  • 1 January 1979
    • journal article
    • research article
    • Vol. 17  (3) , 234-240
Abstract
An experimental method of Ca containing renal stone formation was devised using a rabbit on a normal diet. The stone formation was induced unilaterally, massively and rapidly in an extremely high incidence by temporary obstruction of the upper urinary tract, but not by permanent obstruction. The contralateral kidney was used as a control. The initial stone formation was not solid but muddy and seemed to occur through massive crystal aggregation, resulting in concretion within a few weeks. The mechanism of this stone formation may be crystal aggregation induced by temporary obstruction of the kidney. This animal model contributes to the investigation of the process of crystal aggregation, which is considered to be the most important factor in idiopathic Ca stone formation in man.