RENAL METABOLIC CHANGES RELATING TO CALCULOGENESIS IN AN EXPERIMENTAL-MODEL OF CALCIUM CONTAINING RENAL STONE FORMATION IN RABBITS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 19  (2) , 119-122
Abstract
Histochemical studies showed that sulfated acid glycosaminoglycans (AGAGS) were produced and secreted into the tubular lumen in renal papilla, but not in the renal cortex of muddy stone forming kidney. There was no secretion of sulfated AGAGS in renal papilla histochemically during hydronephrosis before stone formation. On autoradiographic study with the use of 45Ca and 35S for labeling of sulfated AGAGS, 45Ca accumulated in renal papilla of muddy stone forming kidney, but not in the others. 35S apparently accumulated into muddy stones. Measurement of Ca content of the renal papilla and cortex proved the results of autoradiographic studies, and measurement of uronic acid in the urine showed increased secretion of AGAGS in the urine from muddy stone forming kidney. Apparently sulfated AGAGS secreted in the urine could bind calcium crystals to each other and make crystals aggregate massively.