AN INTRACELLULAR HEMOLYSIN OF GROUP A STREPTOCOCCI IV

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Abstract
Extracts of sonically disrupted group A streptococci are lethal for mice upon intravenous injection. This lethal factor is considered to be identical with the intracellular hemolysin on the basis of the following similarities: (a) lability, (b) increased activity with prolonged sonic vibration, (c) influence of peptone in the growth medium, (d) relative particle size as indicated by ultracentrifuge studied, and (e) correlation of hemolytic units and LD50 in sonic extracts obtained from one strain of organism. There are other substances in the crude sonic extract, beside the hemolysin, which contribute to the lethal effect. This lethal-hemolytic factor is distinct from the cellular component responsible for chronic lesions of connective tissue on the basis of the physical, chemical, and immunological properties of this latter factor, which have been well defined.

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