Synthesis of the 4,5-epoxybicyclo[7.3.0]dodecadiyne neocarzinostatin core structure. Surprising compatibility of the 4,5-epoxide with a η2-hexacarbonyldicobalt mediated aldol reaction
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 21,p. 1522-1524
- https://doi.org/10.1039/c39910001522
Abstract
The highly functionalized neocarzinostatin core structure 16 has been synthesized from the enynone 9 in a hexacarbonyldicobalt mediated aldol reaction in which the epoxide ring is unexpectedly not opened.Keywords
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