THE EFFECT OF HEPARIN ON THE ENDOGENOUS LIPEMIA PRODUCED BY PROTRACTED CORTISONE TREATMENT IN THE RABBIT

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Abstract
The clearing effect of heparin on lipemias of alimentary or renal origin is well established. This study was undertaken in order to find out whether heparin will also clear a lipemia of hormonal origin. Lipemia was produced in rabbits by prolonged cortisone treatment. Heparin failed to clear the cortisone-induced lipemia and it did not influence the concomitant hypercholesterolemia, although it exhibited an anticoagulant effect. Despite the long standing lipemia, no atherosclerosis developed in the cortisone treated animals. Some of the possible interpretations of these findings are discussed.