Evidence that Hyaluronidase is Not the Factor in Testicular Extract Causing Increased Vascular Permeability.

Abstract
The intraven. or local admn. of relatively crude bull testis extract is capable of causing increased vascular permeability in rats. Purification of the hyaluronidase component of this extract results in loss of its capacity to induce increased vascular permeability. The purified hyaluronidase appears to retain its spreading activity.