Glucose Metabolism in the Rat During Starvation and Refeeding Following Starvation.

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Abstract
Summary Metabolism of glucose in starved and starved-refed rats was markedly different from pathways observed in non-starved, normal rats. “Supernormal lipogenesis” was observed in liver, heart and kidneys of starved rats, and the lipogenesis was increased some 90-fold in livers of starved-refed rats. The proportion of C14 in “neutral fat” to total fat was increased 2- to 3-fold in hearts and kidneys of starved-refed rats, although the total lipid contents in these organs were not appreciably affected. Neither glucose oxidation nor incorporation of C14 from glucose into lipids by homogenates of rat hearts was affected by prior starvation and refeeding.