Studies on the anti-tumour activity of di- and tri-organotin(IV) complexes of amino acids and related compounds, of 2-mercaptoethanesulphonate, and of purine-6-thiol

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Abstract
The anti-tumour activity of 20 complexes of di- and tri-organotin(IV) has been tested in vivo in P-388 leukaemic mice. The complexes include SnPh2(CysOS)[CysOS =L-cysteinate(2–)], SnR2(Pen)(H2Pen =DL-penicillamine; R = Me, Bun, or Ph), the anions [SnR2(SCH2CH2SO3)2]2–(R = Me, Et, Bun, or Ph), SnMe2(PhCO-GlyO)2(PhCO-GlyO =N-benzoylglycinate), N-substituted glycinates of SnR3(R = Me or Bun), SnBun 2(put)2(Hput = purine-6-thiol), SnR3(put)(R = Me, Bun, or Ph), and (SnPh3)3(put)2. The complex tris(L-cysteinato) bismuth (III) has been investigated also, for comparison purposes. The results are discussed in connection with the structural characteristics, available to date, of the complexes in solution phases.