Acute Hemorrhagic Pancreatitis Associated with Administration of Chlorthalidone

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Abstract
CHLOROTHIAZIDE, since its introduction in 1957, has been followed by a large number of congeners. These agents are benzothiadiazine derivatives which pharmacologically act in the same manner in that they inhibit the reabsorption of sodium by the renal tubules and increase excretion of sodium chloride and potassium.1 , 2 Some uncommon toxic manifestations have been reported as a result of their use. Most of the reports implicate chlorothiazide or hydrochlorothiazide mainly because these compounds were among the first to appear on the market and enjoy a much wider use than the others. The uncommonly reported toxic manifestations have included skin rash, gastrointestinal . . .