Poliomyelitis. I. Propagation of the MEFl Strain of Poliomyelitis Virus in the Suckling Hamster.

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Abstract
The MEF1 strain of poliomyelitis virus (Lansing type (Type 2) has been adapted to suckling hamsters using the intracerebral route of inoculation, whereby 2 sub-strains of virus have been developed which show a much shortened incubation period and a markedly increased concn. of virus in the nervous tissues. The strains adapted to suckling hamsters have been found to cause paralysis after intramusc. or intraperit. inoculation into 21- to 28-day-old mice. Intracerebral inoculations in 20 Rhesus monkeys suggest the MEF1-B substrain of virus has become somewhat reduced in virulence for primates. Two chimpanzees which were fed nervous tissue suspensions of the B substrain remained symptom-free, developed neutralizing antibodies and failed to excrete virus in their stools.