Chronobiology Implications for cancer chemotherapy
- 1 January 1995
- journal article
- review article
- Published by Taylor & Francis in Acta Oncologica
- Vol. 34 (5) , 615-624
- https://doi.org/10.3109/02841869509094037
Abstract
Experimental studies have documented that both the toxicity and the antitumor activity of many cancer drugs are time dependent. Early clinical trials have confirmed this observation for several drugs. The basic concepts of chronobiology and its application to pharmacology are reviewed. As an example, clinical trials of circadian fluoropyrimidine delivery are reviewed. Other clinical results are presented in table form. The mechanisms pertinent to the circadian time dependence of fluoropyrimidines are discussed.Keywords
This publication has 66 references indexed in Scilit:
- Circadian dynamics of tumor necrosis factor alpha (cachectin) lethality.The Journal of Experimental Medicine, 1994
- Improving Responses in Hepatomas with Circadian-Patterned Hepatic Artery Infusions of Recombinant Interleukin-2Journal of Immunotherapy, 1992
- A chronopharmacologic phase II clinical trial with 5-fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancerCancer, 1992
- Circadian pharmacokinetics of methotrexateCancer Chemotherapy and Pharmacology, 1989
- Circadian Timing of Cancer ChemotherapyScience, 1985
- Circadian time dependence of cisplatin urinary kineticsClinical Pharmacology & Therapeutics, 1982
- Circadian Changes of Drug Disposition in ManClinical Pharmacokinetics, 1982
- Circadian rhythms in DNA synthesis and mitosis in normal mice and in mice bearing the Lewis lung carcinomaPublished by Elsevier ,1979
- Clock Mutants of Drosophila melanogasterProceedings of the National Academy of Sciences, 1971
- Comparative Physiology: Diurnal RhythmsAnnual Review of Physiology, 1963