Serum Concentrations of Colistin in Patients with Normal and Impaired Renal Function

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Abstract
A MARKED increase in the incidence of systemic infections due to gram-negative enteric bacilli has been observed in hospitalized patients since the advent of antibiotic therapy.1 , 2 Many of these micro-organisms are relatively insensitive or resistant in vitro to the action of commonly used antibiotics.3 , 4 However, most strains of escherichia, klebsiella-aerobacter and pseudomonas species are susceptible in vitro to colistin,3 , 4 which has been shown to be effective in therapy of infections caused by these micro-organisms.4 5 6 7 To achieve therapeutic serum levels of colistin, intramuscular administration of colistimethate sodium§ must be employed.8 Colistin is excreted in the urine,9 , 10 and excessively high serum concentrations . . .