Effect of High Intakes of Thiamine, Riboflavin and Pyridoxine on Reproduction in Rats and Vitamin Requirements of the Offspring

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Abstract
Female rats were fed during pregnancy and lactation a control diet containing 0.25 mg pyridoxine, 0.4 mg thiamine, and 0.4 mg riboflavin/100 g, or a high pyridoxine, high thiamine, or high riboflavin diet containing the specified vitamin at 25 times the level of the control diet. The levels of these vitamins in the carcasses of the young at birth and in the liver at weaning were determined. The effect of maternal vitamin intake on the vitamin requirements of the young was tested in 2 ways: 1) by comparing the rate of depletion of the young of females fed the high vitamin diets with the rate of depletion of the control group, and 2) by the growth response of the depleted young to graded levels of the vitamin fed in excess in the maternal diet. It was concluded that high intakes of thiamine, riboflavin, or pyridoxine during the reproductive period had no effect on the young, as shown by litter size at birth, growth until weaning, or their vitamin requirements after weaning.