Hemodynamic Effects of L-Hydrazinophthalazine in the Dog, With Special Reference to Circulating Splanchnic Blood Volume

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Abstract
Circulating splanchnic blood volume (SBV) hepatic blood flow (HBF) cardiac output (CO) and mean arterial pressure (MAP) were determined in dogs before and after intravenous administration of l-hydrazino-phthalazine. In observations on 17 dogs it was found that following administration of this agent, MAP fell in association with a rise in CO and in HBF. Thus, total peripheral resistance and splanchnic vascular resistance were decreased. The SBV (Measured by an isotope "dilution technique") increased following the drug from an average of 235 ml to 407 ml. It is suggested that the increase in SBV contributes to failure of the CO to rise sufficiently for the maintenance of MAP. In addition to vascular alterations induced by l-hydrazinophthalazine, total body O2 consumption, ventilation and respiratory rate were increased.

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