New Sesquiterpene Derivatives from the Red Alga Laurencia scoparia. Isolation, Structure Determination, and Anthelmintic Activity
- 10 November 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (12) , 1552-1555
- https://doi.org/10.1021/np0102307
Abstract
Eleven sesquiterpenes (1−11) and one long chain aldehyde (12) have been isolated from the dichloromethane extract of the red alga Laurencia scoparia. Four of them are new natural products. Scopariol (1) is a new natural product with an unusual rearranged chamigrane-type structure. The other three are β-chamigrenes: isorigidol (2), (+)-3-(Z)-bromomethylidene-10β-bromo-β-chamigrene (3), and (−)-3-(E)-bromomethylidene-10β-bromo-β-chamigrene (4). The in vitro activity of compounds 1−12 against the parasitant stage of Nippostrongylus brasiliensis (L4) has been studied.Keywords
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