Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
Top Cited Papers
- 11 June 2004
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 67 (8) , 1216-1238
- https://doi.org/10.1021/np040031y
Abstract
The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases.Keywords
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