THE RATES OF SYNTHESIS AND THE TRANSPORT OF PLASMA FATTY ACID FRACTIONS IN MAN 1

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Abstract
The rates of incorporation of acetate-1-C14 into the fatty acids of the phospholipid and "non-phospholipid" fractions of the plasma of man were determined under normal circumstances. Since the formation and turnover of the fatty acids of the "non-phospholipids" were much more rapid than that of the phospholipid, it was suggested that the "non-phospholipids" may function as the major vehicle for the transport of fatty acids in the plasma. A similar study was performed under conditions whereby utilization of acetate for the biosynthesis of cholesterol was significantly decreased by prefeeding with large quantities of squalene. This failed to alter the incorporation of acetate into the fatty acids. Results of this phase of the investigation are discussed.