DISSEMINATED COCCIDIOIDOMYCOSIS - CLINICAL, IMMUNOLOGICAL AND THERAPEUTIC ASPECTS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 118  (4) , 390-393
Abstract
A patient with disseminated coccidioidomycosis initially had pulmonary and skin manifestations and survived for 14 yr before dying of meningitis due to Coccidioides immitis. In addition to several courses of amphotericin B therapy the patient received injections of transfer factor derived from appropriate donors and miconazole nitrate therapy. The immunologic defense mechanisms of the patient during the course of his disease were studied and the possibility of a cell-mediated immunologic defect, potentially reversible by transfer factor, was demonstrated.