Selectivity in Modification of the Fatty Acid Composition of Normal Mouse Tissues and Membranes in vivo
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Annals of Nutrition and Metabolism
- Vol. 27 (4) , 268-277
- https://doi.org/10.1159/000176687
Abstract
The fatty acid composition of five normal tissues and purified liver plasma membranes of the mouse was modified by feeding diets rich in either coconut or sunflower oil. The phospholipids from the animals fed the coconut oil diets were enriched in monoenoics, and those from the mice fed the sunflower oil diet contained large percentages of polyenoics. Most importantly, there were differences in the extent and type of modification in each tissue. For example, the phospholipids of the heart from animals fed the sunflower oil diet contained 21 % docosapentaenoate compared to less than 6 % in other tissues. The bone marrow from animals fed the coconut oil diets contained a high proportion of saturates, including those of medium chain length. The fatty acyl composition of the neutral lipids was also modified, but in some cases the degree of alteration differed from that occurring in the phospholipids. Purified liver plasma membranes demonstrated diet-induced changes but contained smaller amounts of arachidonate, and those from the animals fed sunflower oil diets were less poly-unsaturated compared to whole liver phospholipids. We conclude that the modification of fatty acid composition of normal tissues induced by experimental diets differs in extent and type. Furthermore, the liver plasma membrane composition is different from that of liver phospholipids. The differences in the extent and type of modification demonstrate selectivity amongst normal tissues.Keywords
This publication has 21 references indexed in Scilit:
- Incorporation of dietary cis and trans isomers of octadecenoate in lipid classes of liver and hepatoma.Journal of Biological Chemistry, 1977
- Effects of dietary saturated andTrans fatty acids on tissue lipid composition and serum LCAT activity in the ratLipids, 1976
- Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanolJournal of Lipid Research, 1964
- A dietary investigation on the variations in phospholipid characteristics of red-cell membranesBiochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects, 1964
- EFFECTS OF DIETARY FATS ON HUMAN ERYTHROCYTE FATTY ACID PATTERNS*Journal of Clinical Investigation, 1963
- A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry, 1957
- Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissueBiochemical Journal, 1955
- STUDIES ON THE TERMINAL ELECTRON TRANSPORT SYSTEM .1. SUCCINIC DEHYDROGENASE1955
- A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITYJournal of Biological Chemistry, 1952
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951