Recombinant vaccines against Marek's disease
Open Access
- 1 April 1998
- journal article
- review article
- Published by Taylor & Francis in Avian Pathology
- Vol. 27 (sup1) , S65-S73
- https://doi.org/10.1080/03079459808419294
Abstract
Novel approaches to vaccination against very virulent (vv) strains of Marek's disease virus (MDV) are discussed. Fowlpox virus (FPV) and herpesvirus of turkeys (HVT) recombinants expressing MDV antigens have been constructed. It has been shown that glycoprotein B of MDV serotype 1 (gB1) is an effective immunogen which is particularly important for conferring protective immunity in genetically susceptible chickens. However, maternal antibodies against MDV diminished the efficacy of vaccination with recombinant FPV‐gB1. HVT recombinants expressing antigens of MDV and Newcastle disease virus have been constructed and have been shown to be effective in preventing Marek's disease as well as systemic Newcastle disease. Maternal antibodies against MDV and Newcastle disease virus did not affect significantly the efficacy of vaccination with cell‐associated HVT recombinants. The potential of retroviral insertion mutagenesis and other means of delivering MDV antigens for immunization are discussed.Keywords
This publication has 44 references indexed in Scilit:
- Protection studies against Marek's disease using baculovirus‐expressed glycoproteins B and C of Marek's disease virus type 1Avian Pathology, 1996
- Extravascular haemolytic anaemia in chicks infected with highly pathogenic Marek's disease virusesAvian Pathology, 1995
- Herpesvirus of Turkey Recombinant Viruses Expressing Infectious Bursal Disease Virus (IBDV) VP2 Immunogen Induce Protection against an IBDV Virulent Challenge in ChickensVirology, 1995
- Insertion of the fusion gene from Newcastle disease virus into a non-essential region in the terminal repeats of fowlpox virus and demonstration of protective immunity induced by the recombinantJournal of General Virology, 1990
- Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus ClassificationJournal of General Virology, 1988
- The structure of Marek disease virus DNA: the presence of unique expansion in nonpathogenic viral DNA.Proceedings of the National Academy of Sciences, 1985
- Field Trials with a Bivalent Vaccine (HVT and SB-1) against Marek's DiseasePublished by JSTOR ,1983
- Most Virus-specific Polypeptides in Cells Productively Infected with Marek's Disease Virus or Herpesvirus of Turkeys Possess Cross-reactive DeterminantsJournal of General Virology, 1983
- Further characterisation of the CVI 988 strain of Marek's disease virusAvian Pathology, 1977
- The Attenuation, with Loss of Oncogenicity, of the Herpes-type Virus of Marek's Disease (Strain hprs-16) on Passage in Cell CultureJournal of General Virology, 1969