Effect of dietary fat and cholesterol on the polyunsaturated fatty acids of cholesterol esters, phospholipids and triglycerides in the liver of the rat

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Abstract
Liver phospholipids were reduced and cholesterol esters and triglycerides were increased as a result of feeding cholesterol to rats. In rats fed with diets containing 5% of various fats for 10 months, the dienoic acid level was high in liver cholesterol esters and phospholipids. Tetraenoic acid level was low in the cholesterol esters and triglycerides and high in phospholipids. The liver phospholipids contained more tetraenoic acid, pentaenoic acid and hexaenoic acid than the cholesterol esters and triglycerides. The levels of polyunsaturated fatty acids of liver lipids decreased greatly on feeding on more saturated fats with and without cholesterol as compared with those obtained when less saturated fats, with and without cholesterol, were fed. Trienoic acids were increased on cholesterol feeding much more in the liver triglycerides than the cholesterol esters and phospholipids.