EXPRESSION OF Ia-LIKE ANTIGENS IN NORMAL HUMAN NONLYMPHOID TISSUES

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Abstract
Ia-like antigen experssion in animal tissues is not restricted to cells associated with immune functions. Whether this phenomenon occurs in normal human tissues was investigated in this study by indirect immunofluorescence on cryostat sections using monoclonal antibodies to Ia-like antigen framework determinants. Ia-like antigens are expressed on several normal human tissues of different embryonic origin. These include the gastrointestinal tract epithelium, urinary bladder, bronchial glands, thymic reticuloepithelial cells (entodermic origin), mammary gland epithelium, acinar cells of parotid, astrocytes (ectodermic origin), alveolar macrophages, Kupffer cells, glomerular and peritubular renal endothelium, endometrium and Langerhans cells (mesodermic origin).