Metabolism of creatine-1-C14 by vitamin E-deficient and hyperthyroid rats

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Abstract
Normal, vitamin E-deficient and hyperthyroid rats were given creatine-1-C14 intraperitoneally, and its incorporation into skeletal muscle was determined. The incorporation of the creatine into skeletal muscle was increased in vitamin E-deficient rats while serum creatine-C14 activity was reduced. Hyperthyroidism led to a decreased incorporation of creatine into skeletal muscle and to elevated serum creatine-C14 levels. It is concluded that in vitamin E deficiency there is an inability of skeletal muscle to retain creatine and that in hyperthyroidism there is a block in the entry of creatine into skeletal muscle.