RECONSTITUTION OF SEMLIKI FOREST VIRUS-INFECTED MICE, INDUCES IMMUNE MEDIATED PATHOLOGICAL-CHANGES IN THE CNS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 52  (1) , 115-120
Abstract
Reconstitution of Semliki Forest virus (SVF) infected nude mice with spleen cells from their immunocompetent nu/+ litter mates resulted in an abolition of the otherwise persistent brain virus, production of anti-SFV IgG and development of normally absent brain pathology. The brain pathological changes, including demyelination, seem to be mediated by T cells, and are maximum 14 days after sensitization of the reconstituting spleen cells. Sensitization of the spleen cells 7 days before transfer to the nude mice results in pathological changes advanced by .apprx. 8 days, compared to reconstitution with unsensitized cells. The involvement of T cells in the virus-induced pathology is discussed.