THE EFFECT OF SODIUM AND POTASSIUM CHLORIDE ON THE RENAL CLEARANCE OF ASCORBIC ACID

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Abstract
Since estradiol benzoate apparently influences the renal tubular mechanism of both ascorbic acid and certain salts, a study was made of the effects of infusion of hypertonic Na and KC1 on the tubular reabsorption of ascorbic acid. The reabsorptive time of ascorbic acid was significantly depressed by these salts, showing that they block the ascorbic acid reabsorptive mechanism in some manner. Possible interfering factors were not found to influence the filtration and reabsorption of ascorbic acid, e.g., increase in the rate of urine flow as the result of osmotic diuretic action by a substance not itself reabsorbed by the tubules (mannitol), and the observation that no significant changes occurred in glomerular filtration rate and renal plasma flow during salt infusion. The evidence does not indicate that ascorbic acid and the salts are reabsorbed by a common transport mechanism, but rather that the salts impair the reabsorptive activity of the tubules for ascorbic acid in some non-specific manner, the nature of which is unknown.

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