Calmodulin‐dependent protein phosphorylation and calcium uptake in rat‐liver microsomes
- 1 May 1984
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 141 (1) , 15-20
- https://doi.org/10.1111/j.1432-1033.1984.tb08149.x
Abstract
A 20‐kDa protein becomes phosphorylated in a process stimulated by Ca2+ and calmodulin in the light microsomal fraction of rat liver homogenate. The uptake of Ca2+ in light microsomal fraction is also calmodulin‐stimulated. The stimulation of Ca2+ transport is associated with the operation of a protein phosphorylation system dependent on Ca2+ and calmodulin. Transport is inhibited by a protein phosphatase which is stimulated by Ca2+ and calmodulin. It is proposed that the phosphorylation of the 20‐kDa protein, which is stimulated by Ca2+ and calmodulin, plays a role in the regulation of the microsomal Ca2+, Mg2+‐ATPase.This publication has 33 references indexed in Scilit:
- Microsomal Ca2+‐ and phospholipid‐dependent protein kinaseFEBS Letters, 1983
- Rat liver plasma membranes contain a lipid‐dependent protein kinase activityFEBS Letters, 1982
- Ca2+ transporting activity of membrane fractions isolated from the post-mitochondrial supernatant of rat liverCell Calcium, 1982
- Localization and properties of a high‐affinity (Ca2+ + Mg2+)‐ATPase in isolated kidney cortex plasma membranesFEBS Letters, 1982
- Calmodulin‐sensitive ATP‐dependent calcium transport by the rat parotid endoplasmic reticulumFEBS Letters, 1982
- Inhibition by phenothiazine antipsychotic drugs of calcium-dependent phosphorylation of cerebral cortex proteins regulated by phospholipid or calmodulinLife Sciences, 1981
- On the role of cyclic AMP and Ca2+—calmodulin‐dependent phosphorylation in the control of (Ca2+ + Mg2+)‐ATPase of cardiac sarcolemmaFEBS Letters, 1981
- Calcium-dependent affinity chromatography of calmodulin on an immobilized phenothiazineBiochemical and Biophysical Research Communications, 1979
- Effect of the phosphorylation of microsomal proteins on the surface potential and enzyme activitiesFEBS Letters, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970