t(18;22)(q21;q11) with rearrangement of BCL2 as a possible secondary change in a lymphocytic lymphoma

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Abstract
We report a lymphocytic lymphoma showing a combination of two characteristic neoplasia‐associated chromosomal changes: trisomy 12, commonly observed in chronic lymphocytic leukemia and lymphocytic lymphoma, and t(18;22)(q21;q11), a variant form of the t( 14; 18)(q32;q21) found in most follicular lymphomas. Southern blot analysis was performed using probes for the 5′ end of the BCL2 gene (18q21) and for the JX as well as CX immunoglobulin genes (22q11). With these two probes, a unique rearranged fragment was detected. Thus the t(18;22)(q21;q11) can be considered as a variant translocation of t( 14; 18)(q32;q21). The karyotypic analysis supports the assumption that in our case trisomy 12 occurred first, and t(18;22) appeared during tumor progression as part of the clonal evolution. This is at variance with the typical t( 14; 18), which has never been found to occur as a secondary change.

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