Macromolecular Drug Conjugates II. Metronidazole-Dextran Prodrugs
- 1 October 1993
- journal article
- research article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 8 (4) , 383-392
- https://doi.org/10.1177/088391159300800406
Abstract
The antimicrobial drug metronidazole was attached to dextran. Two methods of dextran-metronidazole synthesis were studied: (1) the reaction of metronidazole with chloroacetylated derivatives of crosslinked dextran microparticles in basic aprotic solvents, and (2) the reaction of metronidazole chloroacetic acid ester with crosslinked dextran microparticles in basic media. The release of metronidazole from the two types of macromolecular prodrugs was compared.Keywords
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