An analysis of the distribution and dose response of chromosome aberrations in human lymphocytes after in vitro exposure to137Cesium gamma radiation

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Abstract
Summary The chromosome aberration yield for human lymphocytes exposed in vitro to various doses of137Cesium has been studied. Dicentric, total acentric, and excess acentric data were seen to follow a Possion distribution. Calculated total hits demonstrated over-dispersion which could possibly be accounted for by a greater occurrence of single-hit phenomena being repaired than two-hit exchange processes. The resulting distribution generally contained an under-representation of cells with odd numbers of hits and an over-representation of zero- and even-hit classes as compared with Poisson predicted values. The relationship between dicentric yield and dose received in rads was fitted to the linear-quadratic formulaY =αD +βD2 for dicentrics, yielding values of (20.1 ± 3.8) × 10−4 (aberrations/cell)/rad and (1.89 ± 0.75) × 10−6 (aberrations/cell)/rad2 forα andβ respectively. A plot of percent ‘normal’ cells versus the dose in rads resembled cell survival curves and was fitted to the relationP(D) = 100 e−Y whereY =αD +βD2 withα = (23 ± 11) × 10−4 rad−1 andβ = (8.3 ± 2.5) × 10−6 rad−2. A possible use of scoring ‘normal’ cells for purposes of biological dosimetry is presented.

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