Numerical relationship between cells with radiation-induced chromosome aberrations and cells lethally injured by radiation
- 29 February 1980
- journal article
- research article
- Published by Springer Nature in Radiation and Environmental Biophysics
- Vol. 18 (1) , 73-77
- https://doi.org/10.1007/bf01324376
Abstract
Summary The numerical relationship between radiation-induced chromosome aberrations in humanG 0 lymphocytes and reproductive lethality of human bone-marrow lymphocytes is analysed within a large LET interval. The comparison is based upon the evaluation of the coefficient α of the linear component of the corresponding dose-effect-relation for the frequency of cells without aberrations and for the frequency of surviving cells respectively. The good correlation between these coefficients over a large LET interval supports the hypothesis that structural chromosome aberrations and reproductive cell death both result from the same gross chromatin damage.Keywords
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