EFFECT OF INFLAMMATION ON ERYTHROID PRECURSORS (BFU-E AND CFU-E) IN BONE-MARROW AND SPLEEN OF MICE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 92  (1) , 22-29
Abstract
Inflammation, induced in mice by a single i.m. injection of turpentine, caused a long lasting reduction in the number of morphologically unrecognizable CFU-E [late erythroid precursors] in the bone marrow. This resulted in marked decreases in marrow erythroblasts and their Fe incorporation into heme. The effect is attributed to blood-borne mediators of inflammation which either caused an emigration of progenitors of CFU-E from the marrow or inhibited their proliferation, possibly as the result of increases in marrow myelopoiesis. CFU-S [pluripotential hematopoietic stem cells] as well as erythroid and myeloid precursors were markedly increased in the spleen during the inflammatory reaction.