The Corrective Effect of Parathyroid Hormone on Genetic Anomalies in the Dentition and the Tibia of the ia Rat

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Abstract
This roentgenologic and histologic study deals with the effect of parathormone on the dentition and the tibia of the ia rats which are characterized by hereditary hypo-osteoclasis and failure of eruption of teeth. Animals were divided into three groups: Group A consisted of 17 ia rats which were used as controls; Group B of 8 ia rats were given 7 injections of parathormone (total dosage 140 I.U.); and Group C of 12 ia rats received 33 to 39 injns. of parathormone (total dosage 615 to 690 I.U.). Admn. of parathormone resulted in the reduction of the incidence and severity of the dental anomalies, pseudo-odontomas, and,in most of the animals of Group C, in the eruption of teeth. Animals in which admn. was started early and continued longest, showed normal development and eruption of the largest number of teeth. Animals receiving 7 injns. of parathormone did not show reduction of osteosclerosis in the tibia. However, masses of spindle cells were seen in place of hemopoietic cells, ia rats which received 33 to 39 injns. of parathormone showed the beginning of normal modelling resorption and marked reduction of the osteosclerosis in the metaphyses and epiphyses of the tibia. The number of spindle cells had diminished.

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