SOME ASPECTS OF THE METABOLISM OF 16-C14-ESTRONE IN NORMAL INDIVIDUALS*

Open Access
Publisher Website
Google Scholar
Abstract
The physiological disposition of 16-C14-estrone administered intravenously has been studied in 3 normal subjects (2 males and 1 female). The results of blood, urine and feces studied were in accordance with those reported by Beer and Gallagher (Jour. Biol. Chem. 1955, 214, 335) and Sandberg and Slaun-white (Jour. Clin. Invest. 1957, 36, 1266). Investigation on the nature of the urinary metabolites of radioestrone were carried out: 59.40 to 71.95% of the administered dose was excreted in 48 hours with only 42.79 to 62.58% of the administered dose accounted for after the various techniques of hydrolysis. Approximately one-half of the latter values represented metabolites as polar as, or more polar than, estriol. The urinary glucuronoside fraction consisted of: estrone (8.36 to 14.75% of the administered dose), estradiol (2.95 to 4.94%), estriol and more polar compounds (14.06 to 15.72%), 16-ketoestrone (1.82 to 5.85%), 16-epiestriol (1.40 to 3.19%), a mixture of the isomers of 16-ketoestradiol and 16a-hydroxyestrone (1.53 to 3.94%) and a compound which could be 2-methoxyestrone representing 1.37 to 3.97% of the administered dose.