Resin effects in solid-phase peptide synthesis. Enhanced purity of tryptophan-containing peptides through two-step cleavage of side chain protecting groups and peptide–resin linkage
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1653-1655
- https://doi.org/10.1039/c39910001653
Abstract
Alkylation of tryptophan residues during acidic cleavage of tert-butyl side chain protecting groups is reduced in the absence of thiol-scavenging reagents if the peptide remains attached to the solid support throughout the deprotection reaction.Keywords
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