DRUG PHOTO-TOXICITY IN MICE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 58  (2) , 125-130
Abstract
A series of agents with alleged photosensitizing properties was studied in mice by a quantitative in vivo method for acute drug phototoxicity. The method, originally developed for phenothiazine studies, was suitable for several drug groups with varying mechanism of action, e.g., tetracyclines, protoporphyrin and psoralens. In the sulfa group only sulfanilamide was active, although weakly. Phototoxicity in vivo was observed with griseofulvin, nalidixic acid, imperatorin, kynurenic acid and amiodarone.