Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2
- 1 June 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 339 (6227) , 679-684
- https://doi.org/10.1038/339679a0
Abstract
Actively transcribing eukaryotic RNA polymerase II is highly phosphorylated on its repetitive carboxyl-terminal domain. We have isolated a protein kinase that phosphorylates serine residues in this repetitive domain. A component of this kinase is cdc2, the product of a cell-cycle control gene previously shown to be a component of M-phase-promoting factor and M-phase-specific histone H1 kinase. This observation suggests a role for the cdc2 protein kinase in transcriptional regulation.Keywords
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