In vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates ofCandida species

Publisher Website
Google Scholar
Abstract
Cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin B against 102 clinical isolates ofCandida species. At 48 hours all isolates ofCandida albicans, Candida tropicalis, Candida paratropicalis andCandida glabrata were inhibited by ≤5 mcg/ml of cilofungin. In contrast, the MIC90 forCandida krusei was 10 mcg/ml and forCandida parapsilosis >40 mcg/ml. The interaction of combinations of cilofungin with amphotericin B, itraconazole, ketoconazole and flucytosine was additive or indifferent at 48 hours for 100 %, 88 %, 78 % and 70 % of allCandida species isolates, respectively. Overall, cilofungin demonstrated good activity in vitro against mostCandida species isolates.

This publication has 11 references indexed in Scilit: