Hypothalamic Hypogonadism: Induction of Ovulation and Pregnancy by Subcutaneous Pulsatile Injections of Gonadotrophin-Releasing Hormone

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Abstract
Five female patients with isolated hypothalamic hypogonadism were given s.c. pulses of gonadotropin-releasing hormone (GnRH), 2.5-15 .mu.g every 90 min for 2-6 mo. by means of an automated pump. This treatment produced an increase in serum LH [luteinizing hormone] FSH, and estradiol levels in 4 patients, all of whom became pregnant. The estradiol levels failed to rise in 1 patient, in spite of an adequate LH and FSH response, and a subsequent biopsy showed evidence of primary ovarian failure in addition to the hypothalamic deficit. S.c. pulsatile GnRH administration is a simple, safe and relatively inexpensive way to induce ovulation in patients with hypothalamic hypogonadism.

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