CHOLESTEROL METABOLISM IN MAN

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Abstract
Choles-terol-4-C14 was injected intravenously into a man with complete biliary drainage. The routes of excretion and the major compounds to which cholesterol is converted were then studied. Of the administered cholesterol 39.6% was eliminated by all routes of excretion in a 50-hour period. Over 98% appeared in the bile, 1.3% in the acholic feces, and 0.2% in the urine. No C14O2 was found in the expired air. In man the major pathway of cholesterol metabolism apparently involves the conversion of cholesterol to bile acids. The chief excretory product of cholesterol in the bile of man was identified as glycocholic acid.