Influence of Growth Hormone (GH) on Content of GH in the Pituitaries of Normal Rats

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Abstract
Summary Alterations in the content of pituitary GH as estimated by the tibial epi-physeal cartilage assay were produced in rats by the daily, subcutaneous injection of large doses (2 and 6 mg/100 g/day) of bovine GH. An elevation of pituitary GH was observed one day after the first injection of GH. This level returned towards normal after 6 days and the GH content was depressed at 11 days following the initial injection. The injection of saline was without effect on pituitary GH. Blood glucose concentration was slightly elevated at 6 days after the first injection of the higher dose of GH. The rate of weight gain of rats treated with GH was increased. It is suggested that large doses of exogenous GH may alter its secretion by the adenohypophy-sis.